I get this NDR when any of my users try to send to 1 ISP - i need to resolve this urgently any help received. You do not have permission to send to this recipient. For assistance, contact your system administrator. <exchange.local.elthamcollege.vic.edu.au #5.7.1 smtp;550 5.7.1 <abcdef@tpg.com.au>... recipient denied, because MX 10 'mail.elthamcollege.vic.edu.au.' [203.48.142.3] for <ghijk@elthamcollege.vic.edu.au> did not accept the empty address, <>, as required by RFC 821, 1123, 2505, and 2821>

It is possible that on your Global Settings > Properties > Sender Filtering tab you have "Filter Messages with a Blank Sender" checked. Try unchecking that option and try to send the message again. It seems that the receiving server is trying to do a pingback verification with an email that has a blank sender and the server is dropping the email.